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Sports bar
1. RUGBY Dinner No Side Club - 新宿区
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· 62 reviews
3 Chome-10-22 Takada, Toshima City, Tokyo 171-0033, Japan
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4worldlovers: 
Breast cancer is a leading cause of cancer-related death in the women worldwide. Apatinib is a novel tyrosine kinase inhibitor that selectively binds and inhibits vascular endothelial growth factor receptor 2 (VEGFR-2). The clinical trials have demonstrated the objective efficacy of Apatinib against metastatic breast cancer. However, the underlying mechanism is not well established. In the present study, the breast cell lines, BT-474 and MCF-7, were investigated. The effect of Apatinib on the cell viability was determined using CCK-8 assay. The migration, invasion, cell cycle distribution and the downstream signaling of VEGFR-2 in the cells were determined after 48 h treatment with this drug. Subsequently, Vector of angiomotin (AMOT) cDNA was transfected into MCF-7 cells. The cells were either exposed to Apatinib or vehicle and then examined for cell viabilities, migration, invasion, cell cycle distribution and the downstream signaling of VEGFR-2. Apatinib demonstrated a dose-dependent, significant inhibition of cell viabilities, migration and invasion of BT-474 and MCF-7 cells, with an increase in the percentage of cells in G1 phase and a decrease in S phase. In addition, in MCF-7 cells, Apatinib decreased AMOT expression, accompanied with the decreased expression of LATS1/2, YAP, ERK1/2 phosphorylation and cyclin D1. The inhibitory effect of Apatinib on the cell activities and protein expressions were significantly suppressed by AMOT overexpression. The results of this study indicated that Apatinib inhibited MCF-7 cell proliferation and invasion through AMOT/VEGFR-2 pathway.
Breast cancer is a leading cause of cancer-related death in the women worldwide. Apatinib is a novel tyrosine kinase inhibitor that selectively binds and inhibits vascular endothelial growth factor receptor 2 (VEGFR-2). The clinical trials have demonstrated the objective efficacy of Apatinib against metastatic breast cancer. However, the underlying mechanism is not well established. In the present study, the breast cell lines, BT-474 and MCF-7, were investigated. The effect of Apatinib on the cell viability was determined using CCK-8 assay. The migration, invasion, cell cycle distribution and the downstream signaling of VEGFR-2 in the cells were determined after 48 h treatment with this drug. Subsequently, Vector of angiomotin (AMOT) cDNA was transfected into MCF-7 cells. The cells were either exposed to Apatinib or vehicle and then examined for cell viabilities, migration, invasion, cell cycle distribution and the downstream signaling of VEGFR-2. Apatinib demonstrated a dose-dependent, significant inhibition of cell viabilities, migration and invasion of BT-474 and MCF-7 cells, with an increase in the percentage of cells in G1 phase and a decrease in S phase. In addition, in MCF-7 cells, Apatinib decreased AMOT expression, accompanied with the decreased expression of LATS1/2, YAP, ERK1/2 phosphorylation and cyclin D1. The inhibitory effect of Apatinib on the cell activities and protein expressions were significantly suppressed by AMOT overexpression. The results of this study indicated that Apatinib inhibited MCF-7 cell proliferation and invasion through AMOT/VEGFR-2 pathway.
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Rugby field
2. Prince Chichibu Memorial Rugby Ground - 港区
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· 2967 reviews
2 Chome-8-35 Kitaaoyama, Minato City, Tokyo 107-0061, Japan
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Rugby club
3. LIXIL DEERS - 調布市
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· 1 reviews
3 Chome-５２-52 Kikunodai, Chofu, Tokyo 182-0007, Japan
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Bar
4. THE FooTNiK - 渋谷区
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· 320 reviews
Japan, 〒150-0013 Tokyo, Shibuya City, Ebisu, 1 Chome−11−2, 2, Shibuya-ku, Tokyo, アサヒビル 1F Asahi Bldg. 1F
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5. HUB - 新宿区
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· 662 reviews
東陽ビル ２F, 1 Chome-2-5 Kabukicho, Shinjuku City, Tokyo 160-0021, Japan
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Irish pub
6. Britiish Pub&Bar The Cluriaune - 新宿区
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· 52 reviews
Japan, 〒160-0023 Tokyo, Shinjuku City, Nishishinjuku, 7 Chome−16−4, 2F-C, コンシェルジュ髙橋
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Rock music club
7. 1 OAK TOKYO - 麻布十番
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· 186 reviews
1 Chome-4-5 Azabujuban, Minato City, Tokyo 106-0045, Japan
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Pub
8. The Warrior Celt - 台東区
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· 320 reviews
3F, 6 Chome-9-22 Ueno, Taito City, Tokyo 110-0005, Japan
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Sports bar
9. SPORTS&DARTS BAR Sector 7G - 新宿区
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· 136 reviews
Japan, 〒160-0021 Tokyo, Shinjuku City, Kabukicho, 1 Chome−8−1, 佐藤ビル 1階
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Jazz club
10. HUB Asakusa shop - 浅草
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· 321 reviews
1F, 1 Chome-12-2 Asakusa, Taito City, Tokyo 111-0032, Japan
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Pub
11. HUB - 渋谷区
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· 933 reviews
Japan, 〒150-0042 Tokyo, Shibuya City, Udagawacho, 22−2, 渋谷西村總本店ビルB1F
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12. Yokohama Country & Athletic Club (YC&AC) - 中区
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· 224 reviews
11-1 Yaguchidai, Naka Ward, Yokohama, Kanagawa 231-0831, Japan
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Pub
13. HUB Shibuya - 渋谷区
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· 455 reviews
いちごフィエスタ渋谷 B1F, 3-10 Udagawacho, Shibuya City, Tokyo 150-0042, Japan
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14. IRISH PUB CELTS Yaesu - 中央区
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· 388 reviews
三丁目ビル １Ｆ, 3 Chome-2-17 Nihonbashi, Chuo City, Tokyo 103-0027, Japan
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Gastropub
15. Hobgoblin Roppongi British Pub - 六本木
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· 501 reviews
3 Chome-16-33 Roppongi, Minato City, Tokyo 106-0032, Japan
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Rock music club
16. BAUHAUS - 六本木
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· 363 reviews
7-13-2 Urban Building B1, Roppongi, Minato City, Tokyo 106-0032, Japan
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Pub
17. HUB Akihabara - 千代田区
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· 1254 reviews
富士ソフト秋葉原ビル 1F, 3 Kanda Neribeicho, Chiyoda City, Tokyo 101-0022, Japan
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Modern izakaya restaurant
18. MEZZO Luxury Bar & Lounge - 六本木
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· 160 reviews
六本木ストリートビル 1F，2F, 5 Chome-1-7 Roppongi, Minato City, Tokyo 106-0032, Japan
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Pub
19. HUB Shimbashi Ginza Exit - 新橋
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· 423 reviews
カシケイビル B1F, 2 Chome-19-3 Shinbashi, Minato City, Tokyo 105-0004, Japan
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Pub
20. HUB Shinjuku South Exit - 新宿区
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· 569 reviews
Japan, 〒160-0022 Tokyo, Shinjuku City, Shinjuku, 3 Chome−36−15, 新宿内野ビル B1F
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